The Patient Information Leaflet (PIL) is the leaflet included in the pack with a medicine.
Last updated on emc: 02 Feb 2022 Madopar 50 mg/12.5 mg Madopar 100 mg/25 mg Dispersible Tablets Levodopa and benserazide (as hydrochloride)
1. What Madopar is and what it is used for 2. What you need to know before you take Madopar 3. How to take Madopar 4. Possible side effects 5. How to store Madopar 6. Contents of the pack and other information Madopar dispersible tablets contain two medicines called levodopa and benserazide. They are used to treat Parkinson’s disease. People with Parkinson’s disease do not have enough dopamine in certain parts of their brains. This can result in slow movements, stiff muscles and tremor. Madopar works like this:
Do not take Madopar if any of the above applies to you. If you are not sure, talk to your doctor or pharmacist before you take Madopar. Talk to your doctor or pharmacist before taking Madopar if:
Tell your doctor if you or your family/carer notices you are developing urges or cravings to behave in ways that are unusual for you or you cannot resist the impulse, drive or temptation to carry out certain activities that could harm yourself or others. These behaviours are called impulse control disorders and can include addictive gambling, excessive eating or spending, an abnormally high sex drive or an increase in sexual thoughts or feelings. Your doctor may need to review your treatments. If any of the above apply to you, or if you are not sure, talk to your doctor or pharmacist before you take Madopar. Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes medicines that you buy without a prescription and herbal medicines. This is because Madopar can affect the way some medicines work. Also some other medicines can affect the way Madopar works. Do not take Madopar if you have taken a medicine for depression called a ‘non-selective monoamine oxidase inhibitor’ (MAOI) in the last 14 days. These medicines include isocarboxazid and phenelzine. If this applies to you, do not take Madopar and ask your doctor or pharmacist for advice. In particular, tell your doctor or pharmacist if you are taking the following medicines:
If you are going to have an operation, tell the doctor that you are taking Madopar. This is because you may need to stop taking it before you have a general anaesthetic. If you need to have tests on your blood or urine, tell the doctor or nurse that you are taking Madopar. This is because the medicine may affect the results of some tests. Do not take Madopar if you are pregnant, trying to get pregnant or breast-feeding. This is because Madopar may affect your baby. It is important for women to use contraception while taking the medicine. If you get pregnant while taking Madopar, talk to your doctor straight away. Talk to your doctor about driving and using machines or tools, when you take Madopar. This is because one of the medicines in Madopar, levodopa, can make you feel very sleepy. This can happen very quickly, even during the day. You must not drive or use machines if this happens to you. If you are in any doubt about whether you can do a particular activity, talk to your doctor. Always take Madopar exactly as your doctor has told you. You should check with your doctor if you are not sure. How much you take and when you take it is different for different people. How to take your tablets:
You must not stop taking your tablets without talking to your doctor first. This is because if you stop taking the tablets suddenly it can cause something called ‘neuroleptic malignant-like syndrome’ (NMLS). Early signs include increased shaking, sudden high body temperature and muscle problems including stiffness and trouble with balance and keeping upright (postural instability) especially if seen with sweating, paleness and fast heart beat. NMLS can be life threatening. If the above apply to you, talk to a doctor or go to a hospital straight away. If you take more Madopar than you should, talk to a doctor or go to a hospital straight away. Take the medicine pack with you. The following effects may happen if you have taken more tablets than you should: changes in your heart beat, confusion, difficulty sleeping, feeling or being sick and unusual movements of different parts of the body that you cannot control. If someone else takes your Madopar tablets by mistake, they should talk to a doctor or go to a hospital straight away. If you have any further questions on the use of this medicine, ask your doctor or pharmacist. Like all medicines Madopar can cause side effects, although not everyone will get them.
Not known (frequency cannot be estimated from the available data) Stomach and gut:
Heart and circulation:
Blood:
Mental problems:
Impulse Control Disorders: You may experience an inability to resist the impulse to perform an action that could be harmful, which may include:
Tell your doctor if you experience any of these behaviours; they will discuss ways of managing or reducing the symptoms Others:
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.
There are two active substances in Madopar dispersible tablets, and there are two different strengths of tablet available Each Madopar 50 mg/12.5 mg Dispersible Tablets are round and white in colour, have Roche 62.5 marked one side and a score line on the other. Madopar 100 mg/25 mg Dispersible Tablets are round and white in colour, have Roche 125 marked one side and a score line on the other. |